Welcome to ‘News in Research’. On these pages you will find abstracts from the medical and scientific peer reviewed literature which summarize selected research developments in Multiple Sclerosis.
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A Canadian flag beside a summary indicates that one or more of the contributing researchers is Canadian. |
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The MS Society logo beside a summary indicates that the MS Society of Canada has contributed funding to the work described. |
2010
August 27, 2010
Emerging effects of comorbidities on multiple sclerosis
Fatigue, sleepiness, and physical activity in patients with multiple sclerosis
August 23, 2010
A ChIP-seq-defined genome-wide map of vitamin D receptor binding: Associations with disease and evolution
August 19, 2010
Modifiable factors influencing relapses and disability in multiple sclerosis
Hematopoietic Stem Cell Transplantation for Multiple Sclerosis: Collaboration of the CIBMTR and EBMT to Facilitate International Clinical Studies
Recent Papers Highlight Difficulty of Studying Long-Term Impact on Progression of MS Disease-Modifying Therapies
Emerging Therapies in Relapsing-Remitting Multiple Sclerosis
August 10, 2010
Reciprocal Th1 and Th17 regulation by mesenchymal stem cells: Implication for multiple sclerosis
Natalizumab drug holiday in multiple sclerosis: Poorly Tolerated
Improvement in disability after alemtuzumab treatment of multiple sclerosis is associated with neuroprotective autoimmunity
August 5, 2010
A Home-Based Walking Program Using Rhythmic Auditory Stimulation Improves Gait Performance in Patients With Multiple Sclerosis: A Pilot Study
The Effect of Microvascular Decompression in Patients With Multiple Sclerosis and Trigeminal Neuralgia
The natural history of secondary progressive multiple sclerosis
July 29, 2010
Lamotrigine for neuroprotection in secondary progressive multiple sclerosis: a randomised, double-blind, placebo-controlled, parallel-group
Executive Functioning in Children and Adolescents with Multiple Sclerosis
Nocebo effects in multiple sclerosis trials: a meta-analysis
Migraine is comorbid with multiple sclerosis and associated with a more symptomatic MS course
July 22, 2010
Impact on activities of daily living using a functional electrical stimulation device to improve dropped foot in people with multiple sclerosis, measured by the Canadian Occupational Performance Measure
Reconstitution of circulating lymphocyte counts in FTY720-treated MS patients
July 20, 2010
Two Medical Meetings (ACTRIMS and CMSC) Focus on Research Progress and Issues in MS Clinical Care
July 12, 2010
Surrogate endpoints for EDSS worsening in multiple sclerosis. A meta-analytic approach.
July 6, 2010
A phase I/II dose-escalation trial of vitamin D3 and calcium in multiple sclerosis
Cardiotoxicity and other adverse events associated with mitoxantrone treatment for MS
Two-year study of cervical cord volume and myelin water in primary progressive multiple sclerosis
July 1, 2010
New perspectives in the natural history of multiple sclerosis
The natural history of multiple sclerosis, a geographically based study: relapses and long-term disability
Increasing use of disease modifying drugs for MS in Canada
June 23, 2010
Rituximab add-on therapy for breakthrough relapsing multiple sclerosis: A 52-week phase II trial
Cross-sectional study assessing long-term safety of interferon-{beta}-1b for relapsing-remitting MS
June 21, 2010
Fatigue in multiple sclerosis: associations with health-related quality of life and physical performance
June 14, 2010
MRI only conversion to multiple sclerosis following a clinically isolated syndrome
June 7, 2010
What is the risk of permanent disability from a multiple sclerosis relapse?
Evidence Report: The efficacy and safety of mitoxantrone (Novantrone) in the treatment of multiple sclerosis
June 3, 2010
Vitamin D and multiple sclerosis
Progress on Experimental Therapies for MS, CCSVI Forum, and Much More, Reported at the American Academy of Neurology Meeting
June 1, 2010
Wallerian Degeneration: A Major Component of Early Axonal Pathology in Multiple Sclerosis
Memantine for cognitive impairment in multiple sclerosis: a randomized placebo-controlled trial
May 31, 2010
Cardiotoxicity and other adverse events associated with mitoxantrone treatment for MS
May 25, 2010
Researchers pave way for the first coordinated international approach to MS stem cell research
Psychosocial issue in children and adolescents with multiple sclerosis
May 19, 2010
Crossover trial of gabapentin and memantine as treatment for acquired nystagmus
May 10, 2010
Fingolimod (FTY720) Enhances Remyelination Following Demyelination of Organotypic Cerebellar Slices
Study Suggests that Smoking and Exposure to Epstein-Barr Virus May Interact as Risk Factors for Developing MS
April 26, 2010
Disease onset in familial and sporadic primary progressive multiple sclerosis
Factors associated with delay to medical recognition in two Canadian multiple sclerosis cohorts
April 22, 2010
Relationship of cortical atrophy to fatigue in patients with multiple sclerosis
Clinical trial of a formal group fatigue program in multiple sclerosis
April 7, 2010
Pediatric focus continues to shed new light on MS
March 23, 2010
Five Studies explore relationship between Epstein-Barr Virus and MS
March 17, 2010
Early cognitive impairment in multiple sclerosis predicts disability outcome several years later
Ibudilast in relapsing-remitting multiple sclerosis
March 16, 2010
Antiviral immune response in patients with multiple sclerosis and healthy siblings
March 4, 2010
Results of Phase II "CHOICE" Study Published, Showing that Daclizumab Reduced Disease Activity in Relapsing MS, and Revealing Novel Immune Mechanism
March 3, 2010
Clinical effect of neutralizing antibodies to interferon beta that persist long after cessation of therapy for multiple sclerosis
MRI of the corpus callosum in multiple sclerosis: association with disability
Genome-wide Association Study in a High-Risk Isolate for Multiple Sclerosis Reveals Associated Variants in STAT3 Gene
March 1, 2010
Atorvastatin Combined with Interferon to Verify the Efficacy (ACTIVE) in relapsing-remitting active multiple sclerosis patients: a longitudinal controlled trial of combination therapy
February 16, 2010
High field (9.4 Tesla) magnetic resonance imaging of cortical grey matter lesions in multiple sclerosis
February 2, 2010
The rising prevalence and changing age distribution of multiple sclerosis in Manitoba
January 29, 2010
Sustained-release oral fampridine in multiple sclerosis: a randomised, double-blind, controlled trial
Interferon-gamma-producing T cells, pregnancy, and postpartum relapses of multiple sclerosis
January 28, 2010
Results Published from Phase 3 Study of Oral Cladribine in Relapsing-Remitting MS
January 27, 2010
Positive Results Published on Clinical Trials of Oral FTY720 (Fingolimod) for Relapsing MS - Novartis Applies to FDA and European Regulatory Agency for Approval
January 26, 2010
Regional brain atrophy in primary fatigued patients with multiple sclerosis
January 21, 2010
No Effect of Parental Age on Risk of Multiple Sclerosis: A Population-Based Study
January 12, 2010
Phase II study of oral fingolimod (FTY720) in multiple sclerosis: 3-year results
January 11, 2010
A randomized trial of memantine as treatment for spasticity in multiple sclerosis
January 8, 2010
HLA-DRB1 and month of birth in multiple sclerosis
January 4, 2010
Callosal lesion predicts future attacks after clinically isolated syndrome
A short-term randomized MRI study of high-dose oral vs intravenous methylprednisolone in MS.
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2009
December 10, 2009
Positive Results Announced in Phase II Study of IV Ocrelizumab in Relapsing-Remitting MS
November 24, 2009
Body size and risk of MS in two cohorts of US women
November 21, 2009
Chronic cerebrospinal venous insufficiency (CCSVI) and MS - Overview and FAQ
November 18, 2009
Impact of Multiple Sclerosis Relapses on Progression Diminishes with time
November 9, 2009
Rituximab in patients with primary progressive multiple sclerosis: results of a randomized double-blind placebo-controlled multicenter trial
October 27, 2009
Efficacy and specificity of intensive cognitive rehabilitation of attention and executive functions in multiple sclerosis
Consideration of the risk of secondary leukemia after mitoxantrone in multiple sclerosis populations is required
October 20, 2009
Two reports for Management of Trigeminal Neuralgia in Multiple Sclerosis
PreCISe Study Results – Showing Benefit of Copaxone® in People at High Risk for MS
October 15, 2009
Therapeutic Strategies for MS and More Highlighted at ECTRIMS Conference
October 13, 2009
Preliminary work suggests that minocycline as add-on therapy may offer improved efficacy of glatiramer acetate in relapsing-remitting multiple sclerosis. Authors suggest further research needed.
September 22, 2009
250 mug or 500 mug interferon beta-1b versus 20 mg glatiramer acetate in relapsing-remitting multiple sclerosis: a prospective, randomised, multicentre study
Asymptomatic reactivation of JC virus in patients treated with natalizumab
September 10, 2009
Correlation between disability and transcranial magnetic stimulation abnormalities in patients with multiple sclerosis
September 9, 2009
Effect of immigration on multiple sclerosis female to male ratio in Canada: the Canadian Collaborative Study
September 3, 2009
Smoking is associated with increased lesion volumes and brain atrophy in multiple sclerosis
Gestational diabetes and multiple sclerosis
September 2, 2009
Care Given to People with MS by Family Members Presents Unique Challenges - Study funded by National MS Society points to need for respite and mental health support for family care givers
August 31, 2009
Sponsor Reports Positive Results of Clinical Trial of Zenvia™ for Pseudobulbar Affect (Uncontrollable Laughing and/or Crying)
August 18, 2009
Pilot study of a cognitive intervention program for persons with multiple sclerosis.
July 30, 2009
The impact of physical activity on fatigue, depression and quality of life in persons with multiple sclerosis
July 29, 2009
Dirucotide Does Not Meet Primary Endpoint in Phase III MAESTRO-01 Trial In Secondary Progressive Multiple Sclerosis
July 28, 2009
Study Adds Evidence that Smoking Worsens MS, and Quitting May Help
July 22, 2009
"Benign” Course of MS Evaluated with MRI and Other Imaging Methods by European Collaborators
July 6, 2009
Parent-of-origin effect in multiple sclerosis. Observations from interracial matings
Age of onset in concordant twins and other relative pairs with multiple sclerosis
Two Studies Report Finding New Genes and Gene Regions that Make People Susceptible to MS
June 29, 2009
Assessing the clinical efficacy of sildenafil for the treatment of female sexual dysfunction
Effect of statins on clinical and molecular responses to intramuscular interferon beta-1a
June 24, 2009
Two Medical Meetings (ACTRIMS and CMSC) Focus on MS Risk Factors and Quality of Life Issues
June 23, 2009
Remyelination capacity of the MS brain decreases with disease chronicity
June 17, 2009
Efficacy of intramuscular interferon beta-1a in patients with clinically isolated syndrome: analysis of subgroups based on new risk criteria
June 15, 2009
Randomized Clinical Trial of Balance-Based Torso Weighting for Improving Upright Mobility in People with Multiple Sclerosis
June 9, 2009
Report of American Academy of Neurology Meeting Seattle April 2009
June 8, 2009
Parity and secondary progression in multiple sclerosis
May 26, 2009
Update on oral therapies for MS reported at the American Academy of Neurology Meeting
May 19, 2009
Greater loss of axons in primary progressive multiple sclerosis plaques compared to secondary progressive disease
May 14, 2009
The relationship between handedness and risk of multiple sclerosis
May 11, 2009
Multiple Sclerosis and Academic Work: Socio-Spatial Strategies Adopted to Maintain Employment
May 4, 2009
The clinical and urodynamic results of a 3-month percutaneous posterior tibial nerve stimulation treatment in patients with multiple sclerosisrelated neurogenic bladder dysfunction
April 30, 2009
Thalamic involvement and its impact on clinical disability in patients with multiple sclerosis: a diffusion tensor imaging study at 3T
The search for responsive clinical endpoints in primary progressive multiple sclerosis
April 20, 2009
Prevalence and impact of pain in multiple sclerosis: physical and psychologic contributors
April 14, 2009
Pain and quality of life in the early stages after multiple sclerosis diagnosis: a 2-year longitudinal study
March 25, 2009
Efficacy of treatment of MS with IFN{beta}-1b or glatiramer acetate by monthly brain MRI in the BECOME study
March 18, 2009
Studies Reported: Function, Combination Drug Therapy, Cognition, and Causation
March 17, 2009
Genetics Studies Yield New Clues to Why People Get MS
March 16, 2009
New Studies Bolster Possible Link Between Epstein-Barr Virus and MS
March 6, 2009
Predicting accidental falls in people with multiple sclerosis -- a longitudinal study
March 3, 2009
Young Smokers Increase Risk for Multiple Sclerosis
March 3, 2009
Breastfeeding may have an impact on reducing Multiple Sclerosis Relapses
February 23, 2009
Results of the Avonex Combination Trial (ACT) in relapsing-remittng MS
February 11, 2009
Incidence of acquired demyelination of the central nervous system in Canadian children
February 9, 2009
Researchers Report Good Results from Small Study of Stem Cell Therapy to “Reboot” Immune System in MS
February 5, 2009
Genetic study supports vitamin D deficiency as an environmental factor in MS susceptibility
January 28, 2009
Oral Cladribine Reduces MS Relapses in Phase 3 Clinical Trial
January 15, 2009
Restless Leg Syndrome in multiple sclerosis:A case-control study
January 8, 2009
Physical activity and quality of life in multiple sclerosis: intermediary roles of disability, fatigue, mood, pain, self-efficacy and social support.
January 5, 2009
Oral FTY720 (Fingolimod) Reduced Relapse Rate More Effectively Than Avonex in Initial Results of One-Year Study in Relapsing-Remitting MS
January 5, 2009
Dr. Brenda Banwell, a well known Canadian pediatric researcher, is an author on 2 papers about the use of MRI in children with MS, published in Neurology.
2008 Nov 26 (Epub ahead of print).
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2008
November 17, 2008
Researchers find a key player in the maintenance of myelin
November 13, 2008
Researchers demonstrate a potential association between monthly ambient sunlight, infections and relapse rates in Multiple Sclerosis
(Neuroepidemiology 2008, 31: 271-279)
November 4, 2008
Results Published: Oral Drug BG00012 Reduced MRI Inflammation
in Relapsing-Remitting MS During Phase 2 Trial
November 3, 2008
Alemtuzumab Results Published: Reduced MS Relapses and Accumulation
October 27, 2008
Teams Funded by the National MS Society Report
on Key Enzymes Related to MS Progression and Nervous System Repair
October 16, 2008
Investigators Find No Overall Link Between Hepatitis B Vaccine
and MS
October 2, 2008
World congress on MS takes
place in Montreal
September 10, 2008
Higher levels of 25-hydroxyvitamin D are associated with a lower
incidence of multiple sclerosis only in women
September 3, 2008
New Recommendations from the FDA Concerning
the Monitoring of Cardiac Function in People Taking Mitoxantrone
August 21, 2008
Canadian Collaborative Project on Genetic Susceptibility to
MS provides data to study exploring risk of developing MS for
preterm babies
August 18, 2008
Researchers suggest that latitude and sex ratio trends in the
incidence of multiple sclerosis may be shifting
August 13, 2008
Biogen Idec and Elan Pharmaceuticals
informed drug regulatory authorities about two new confirmed
cases of
PML(progressive
multifocal leukoencephalopathy) in individuals who were taking
Tysabri® (natalizumab) as a monotherapy (not in combination
with other therapies).
August 13, 2008
Smoking is a risk factor for early conversion to clinically definite
multiple sclerosis
August 13, 2008
Sleep problems in people with MS are prevalent
July 7, 2008
Effectiveness of Rehabilitation Intervention in
Persons with Multiple Sclerosis: A randomized controlled trial
July 3, 2008
Laquinimod Results Published: Oral Drug Reduces
Disease Activity in Phase 2 Study
June 27, 2008
Molecule Strikes Balance in Immune System and
May Be Key to Autoimmune Attack in MS
June 13, 2008
Serious Infections Experienced by Two People Participating in
Clinical Trials of FTY720 for MS
June 11, 2008
Fampridine-SR Improves Walking Speed in All Types
of MS in Second Phase 3 Study
June 10, 2008
New Study Suggests Immune Genes Help Determine Sites of MS Damage and Symptoms
May 23, 2008
Progress on Experimental Therapies for MS, and
Much More, Reported at the American Academy of Neurology Meeting
May 15, 2008
Stem Cell Treatments in China
April 29, 2008
Disappointing Results from Trial of Rituximab
in Primary Progressive MS
April 22, 2008
Investigators Explore MS Risk Conferred by Combination of Gene
and Virus
April 21, 2008
Norwegian Researchers Confirm Higher Rates of Symptoms of Depression
and Anxiety in People with MS
April 3, 2008
Combined treatment with atorvastatin and minocycline suppresses
severity of EAE
April 2, 2008
Acne medication may delay progress of multiple
sclerosis
March 27, 2008
Compound Protects Nerves from Injury in National MS Society-funded
Study of Mice with Progressive MS
February 28, 2008
"Street" Marijuana Harmful
to Cognitive Function in MS Patients
February 19, 2008
Phase ll trial suggests Rituximab may reduce MS Disease Activity
January 16, 2008
MS Therapy may help delay conversion from CIS to clinically
definite MS
January 11, 2008
Two year pilot study suggests that
combination therapy with interferon Beta-1b and azathioprine
may help slow the course of SPMS
January 9, 2008
Large-scale analysis from Nova
Scotia suggests that disease-modifying drugs for MS are effective
in reducing
disability
progression
in people whose MS started with relapses
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2007
November 6, 2007
Researchers Report Findings on Antibody That Stimulates Myelin
Repair
October 31, 2007
Research Progress Reported at International
ECTRIMS Meeting
October 31, 2007
Eye Scan May Help Diagnose, Treat MS
October 25, 2007
Acne medication may delay
progress of multiple sclerosis
September 19, 2007
Parental smoking at home and the risk of childhood-onset multiple sclerosis in children
August 17, 2007
Experimental MS vaccine shows beneficial changes
in immune system
August 14, 2007
Interferon injection may delay disability accumulation
August 8, 2007
Study Finds Early Sun Exposure Associated with Reduced Risk of
MS
July 31, 2007
International Collaborators Identify New Genetic
Risk Factors for MS
July 25, 2007
A timing-of-birth effect on risk for multiple sclerosis
July 23, 2007
Immune system variations may underlie differences
in MS between African Americans and Caucasians
July 18, 2007
ACTRIMS and CMSC
meetings focus on emerging MS therapies and quality of life issues
June 2007
MS Disease-Modifying
Therapies in Canada only
May 24, 2007
Easier access to multiple
sclerosis treatments will reduce overall healthcare costs: MS
Society
May 8, 2007
The Canadian
endMS Research Conference - Banff, Alberta
- December 10 to 13, 2007
May 2007
Progress on Experimental
Therapies for MS, and Much More, Reported at the American Academy
of Neurology Meeting - April 28 to
May 4, 2007
April 13, 2007
Researchers Stop MS-like disease in Mice by Targeting a Blood
Protein
April 13, 2007
Frequently Asked Questions on Tysabri
February 22, 2007
Clinical trial of oral therapy in relapsing remitting MS
February 22, 2007
Pregnancy hormone key to repairing nerve cell damage
February 12, 2007
Benign MS
January 29, 2007
Clinical trial results
for oral therapy fingolimod show reduction of disease activity:
Larger study now recruiting participants
January 24, 2007
Clinical trial of MBP8298 expands to United States
January 4, 2007
Later onset of MS does
not necessarily lead to worse outcome: University of British
Columbia study
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2006
November 22, 2006
Sex Hormone Trial in Women with MS Launched
November
1, 2006
Abnormal liver test results found in people with multiple sclerosis
in placebo arms of clinical trials
October 31, 2006
Canadian
study finds MS increasing among women
October 4, 2006
Health Canada approves Tysabri for treatment of relapsing MS
September 29, 2006
Vitamin
B3 protects nerve tissue from further damage in mice with MS-like
disease
September 6, 2006
Transmission of MS to children: Study finds men transmit MS more often to their children than do women
August
22, 2006
Clinical trial of oral therapy: Fingolimod study will involve 1,250
participants
August 10, 2006
Health
Canada approves Betaseron for treatment of first clinical
event suggestive
of MS
August
9, 2006
Study
suggests tetanus vaccination associated with lower risk of
developing MS
August
8, 2006
Place
of residence in childhood may influence development of MS
risk
July 27, 2006
Small study combines Novantrone and Copaxone as potential MS treatment
June 23, 2006
Small Edmonton-based
clinical trial shows some slowing of disease progression
June 2, 2006
FDA approves Tysabri's
return to market in USA for relapsing MS
May 2, 2006
MS experts estimate number
of Canadians with MS is 55,000 to 75,000
April 20, 2006
Reporting from the AAN:
Promising MS Clinical Trial Results
April 7, 2006
Recruitment of participants underway for combination
therapy study
April 7, 2006
Clinical trial for
oral Lipitor still enrolling participants for study
February-24-2006
Clinical trial underway
for new monoclonal antibody daclizumab
February-24-2006
Tysabri Update: FDA permits some clinical
trial participants to resume treatment
Jan-24-2006
BC researchers find disability progression in MS is slower
than previously reported
Jan-20-2006
Status of rituximab in multiple sclerosis
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